archerbreak0946

BACKGROUND AND AIMS The prevalence of malnutrition is over 70% in advanced cancer patients and impacts negatively on survival and quality of life. Artificial nutrition can be integrated into a home palliative care program. This observational study aims to describe the criteria for identifying the cancer patients that could benefit from home artificial nutrition (HAN) and to evaluate its impact on survival and performance status. METHODS The selection criteria for patient's eligibility to HAN were Karnofsky Performance Status (KPS) ≥40, life expectancy ≥6 weeks, inadequate caloric intake ± malnutrition, suitable psycho-physical conditions and informed consent. The access route for nutritional therapy (home parenteral nutrition, HPN; home enteral nutrition, HEN) was chosen according to the ESPEN Guidelines. The parameters considered were primary site of the tumor; oral food intake; nutritional status; stage of cachexia; fluid, energy and protein supplied by HAN; survival. RESULTS From 1990 to 2019, 43,474 cancetion of the patient who can take advantage of HAN. HAN can be effective in avoiding death from malnutrition in 73% of patients, and in maintaining or improving the KPS at one month in 90% of cases. The benefits provided by HAN on survival and performance status depend on the cachexia degree at the entry. BACKGROUNDS AND AIMS Atherosclerosis and its associated cardiovascular disease (CVD) represent a major global health problem worldwide and vascular dysfunction is important in its pathogenesis. Clinical trials investigating the effect of garlic on vascular function measured by several non-invasive methods and their results are inconsistent. This study aimed to summarize the current evidence regarding the effectiveness of garlic as one of the world's most ancient medicines on measures of vascular reactivity and/or stiffness in adults. METHODS All published RCTs in English were systematically searched on PubMed, Scopus and Google Scholar search engines up to Oct 2019. The exposure and outcome variable of interest were garlic and vascular function measurements. Ten trials which met inclusion criteria were included in this study. RESULTS A total of 45 studies were found through search databases. After excluding duplicates, the 25 remaining studies were screened by title and abstract which 15 of them excluded. Finally, ten trials were included in this review study, which were published between 2004 and 2018. CONCLUSIONS Findings were inconsistent. However, garlic has the potential to improve vascular function, particularly in subjects with cardiovascular risk factors. Additional human studies on garlic and its constituents should consider the population and the specific type of garlic preparation. BACKGROUND & AIMS Sarcopenia is a commonly prevalent malnutrition condition and serves as a valuable adverse prognostic indicator for survival in patients with cancer. A rapid and convenient screening test for sarcopenia would be helpful for patients. Aim of the study was to evaluate the diagnostic value of SARC-F and SARC-F combined with calf circumference (SARC-CalF) for screening cancer-related sarcopenia in cancer population. METHODS A total of 309 patients with cancer who had routine abdominal comptued tomography (CT) images within 30 days were enrolled in this cross-sectional cohort. Sarcopenia was determined as the presence of both low muscle mass (LMM) and low muscle strength; muscle mass was evaluated by CT-scan, and muscle strength was evaluated by handgrip strength (HGS). Two different diagnostic criteria (Western criteria and Eastern criteria) were used as the reference standards. The sensitivity and specificity analyses of the SARC-F and SARC-CalF were calculated. The receiver operating charactertivity and overall diagnostic accuracy of SARC-F for screening sarcopenia. SARC-CalF can be a rapid screening tool for sarcopenia in patients with cancer. A series of novel 2-arylbenzimidazoles have been designed, synthesized and evaluated for their inhibitory activity against IDH2 R140Q mutant. The preliminary results indicated that four compounds 7b, 7c, 7m and 7r displayed the potent inhibitory activity against IDH2 R140Q mutant. Among them, compound 7c showed the highest inhibitory activity, with the IC50 value of 0.26 μM, which was more active than positive control enasidenib. The exquisite selectivity of 7c for IDH2 R140Q mutant isoform was demonstrated by the poor activity against the IDH1 R132C mutant, IDH1 R132H mutant, wild-type IDH1, IDH2 R172K mutant and the wild-type IDH2. Hydrolysates of an emetic toxin cereulide were found in the broth of Bacillus cereus. The ester cleaved depsipeptides of cereulide were synthesized using liquid phase fragment condensation method starting from commercially available amino acids. https://www.selleckchem.com/products/aspirin-acetylsalicylic-acid.html The chemical structure of hydrolysates was verified tetradepsipeptide l-O-Val-l-Val-D-O-Leu-d-Ala and dodecadepsipeptide (D-O-Leu-d-Ala-l-O-Val-l-Val)3 using LC-TOFMS. Quantitative analysis of cereulide in the broth revealed production of cereulide in the stationary phase and decomposition in the death phase. The increase in tetradepsipeptide continued after the stationary phase until decomposition occurred. This study aimed to evaluate the accuracy of 3D L5/S1 moment estimates from an ambulatory measurement system consisting of a wearable inertial motion capture system (IMC) and instrumented force shoes (FSs), during manual lifting. Reference L5/S1 moments were calculated using an inverse dynamics bottom-up laboratory model (buLABmodel), based on data from a measurement system comprising optical motion capture (OMC) and force plates (FPs). System performance of (1) a bottom-up ambulatory model (buAMBmodel) using lower-body kinematic IMC and FS data, and (2) a top-down ambulatory model (tdAMBmodel) using upper-body kinematic IMC data and hand forces (HFs) were compared. HFs were estimated using full-body kinematic IMC data and FS forces. Eight males and eight females lifted a 10-kg box from different initial vertical/horizontal positions using either a free or an asymmetric lifting style. As a measure of system performance, root-mean-square (RMS) errors were calculated between the reference (buLABmodel) and ambulatory (tdAMBmodel &buAMBmodel) moments.