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Tuberculosis associated Immune reconstitution inflammatory syndrome (IRIS) in a HIV negative patient can present with a multitude of clinic-radiological presentations that are often confused with drug resistance/treatment failure. Being a diagnosis of exclusion, this clinical entity is often prone to under-diagnosis. We present a series of 5 patients who presented with varied but uncommon IRIS manifestations. High index of suspicion coupled with clinical reasoning and judicious use of phenotypic and genotypic culture methods helped in their timely detection and successful treatment. Guillain-Barre syndrome (GBS) is a life-threatening immune-mediated acute inflammatory polyneuropathy and is associated with various antecedent infections. Its association with tuberculosis is very uncommon with only a handful of cases being reported in the literature. It's association with tuberculous meningitis is even more scarce with only one case reported in literature till date. We report a 40-year-old lady with GBS associated with tuberculous meningitis. GBS was confirmed with clinical examination and nerve conduction studies. Tuberculosis (TB) is a disease of diverse manifestations. https://www.selleckchem.com/products/cariprazine-rgh-188.html In children, neurotuberculosis is the severest form, which when left untreated can have deleterious consequences. There has been reports on pediatric TB meningitis manifesting with fever and seizures, altered sensorium or focal deficits. There are reports on TB meningitis presenting with cognitive decline in adults. We are reporting a eleven month old girl child who presented with acute regression of attained developmental milestones of one month duration as the only presenting complaint and MRI brain revealed basal exudates with hydrocephalus which nailed the diagnosis of tuberculous meningitis. CSF (Cerebro Spinal Fluid) tested by CBNAAT (Cartridge Based Nucleic Acid Amplification Testing) for TB was negative, but gastric aspirate tested for the same, came positive. Tuberculin skin testing was also positive. Chest X-ray was normal. The child had not received BCG (Bacillus Calmette Guerin)vaccine, thereby increasing her risk of complicated TB. The contact couldn't be traced. The child was started on ATT (Anti Tubercular Treatment) as soon as the diagnosis was made and she improved, thus signifying the better outcome with early initiation of ATT. This case reporting is intended to highlight the unusual presentation of TB meningitis in children, which when clinicians are aware of will lead to early treatment and better prognosis. Countries with tuberculosis as an endemic disease face many challenges. Isolated tubercular tenosynovitis is a rare presentation of extrapulmonary tuberculosis and involvement of the ankle is even rare. We present a case of isolated tubercular tenosynovitis of the ankle, the diagnosis of which was suggested radiologically and confirmed by histopathology. Clinicians dealing with tuberculosis infected patients need to be aware of such rare presentations for proper diagnosis and management. BACKGROUNDS Health care workers (HCWs) are globally known to have high risk of tuberculosis (TB) infection while risk factors of TB infections among HCWs are still inconclusive. OBJECTIVES To perform a meta-analysis in effort to identify risk factors of TB infection among HCWs. METHODS A meta-analysis was conducted between February and July 2019. Papers were searched in Pubmed, Embase, Cochrane, and Web of science and information of interest were extracted. The correlation and effect estimation were analyzed using random or fixed effect model. RESULTS A total of 12 studies consisting of 2871 cases and 15,673 controls were included and six risk factors were available for meta-analysis. Cumulative calculation found that age, working duration, and types of job were significant risk factor of TB infection while gender, active TB contact, and types of workplace were not associated significantly with TB infection among HCWs. Our pooled data revealed that decreased risk of TB infection was observed in age less than 30 years (age  less then  30 years vs. age ≥ 30 years) and working duration less than five years (working duration  less then  5 years vs. ≥5 years). Being more than 40 years, working more than 10 years, and being physicians increased the risk of TB infection significantly compared to age ≤40 years, working duration ≤10 years, and other job types, respectively. CONCLUSIONS Our meta-analysis has identified the significant risk factors of TB infection among HCWs. Our results may be useful for establishing future TB prevention program among HCWs. Female genital tract tuberculosis (FGTB) is a chronic disease with varied presentation. The diagnosis of FGTB for early institution of treatment remains a clinical challenge. Its laboratory diagnosis is difficult because of paucibacillary nature of the condition and limitation of available diagnostic tests. In view of the intricate problems in diagnosis of FGTB, physicians tend to over treat with empirical anti-tuberculosis drugs. Apart from concerns of drug toxicity, this may be a contributing factor in the increasing incidence of multidrug-resistant TB reported in India. The main goal for advances in TB diagnostics is to reduce delay in diagnosis and treatment. In addition, there should be reduced complexity, improving robustness, and improving accuracy of the laboratory test for diagnosis of Female genital tuberculosis. OBJECTIVE This narrative review is written with the following objectives. 1) To get a comprehensive overview as well as recent advances in diagnostic test used in the detection of FGTB. 2) he accurate and timely diagnosis of FGTB. BACKGROUND The Revised National Tuberculosis Control Program (RNTCP) envisages shifting from thrice-weekly to a daily anti-tuberculosis treatment (ATT) regimen. The potential merits and demerits of both regimens continue to be debated. METHODS This retrospective study compared treatment outcomes in 191 HIV-negative, newly diagnosed, sputum-positive adults with pulmonary tuberculosis from Vellore district of Tamil Nadu who were treated at a private medical college during 2009 to 2012 with intermittent Directly Observed Treatment Short Course (intermittent DOTS cohort, n=132) or who opted for daily Self-Administered Treatment (daily SAT cohort, n=59). Treatment outcomes obtained from medical records were supplemented by interviews with consenting, traceable patients. RESULTS The rates for the RNTCP-recommended sputum smear examinations were suboptimal (42% for daily SAT and 72% for intermittent DOTS). However, treatment success with daily SAT and intermittent DOTS (76.2% vs. 70.4%); default (11.9% vs. 18.2%); death (6.