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Cancer is one of the leading causes of death in the world affecting millions of people. The commercially available anticancer drugs lack the selectivity and show several undue side effects during the biologically targeted therapy, thus calling for the exploration of wider chemical space to furnish new structural leads with promising anticancer potential. In this endeavor, we synthesized a series of coumarinyl thiazolotriazoles with diverse functional group tolerance and will be tested for their anticancer properties against cancer cell lines (HeLa? and MCF-7) and a normal cell line (BHK-21). To overcome such complications, in the current study, we evaluated the cytotoxic effects of coumarinyl thiazolotriazoles hybrids on human breast adenocarcinoma (MCF-7), cervical adenocarcinoma (HeLa?) cells and normal cells i.e., baby hamster kidney cells (BHK-21) using MTT (dimethyl-2-thiazolyl-2,5-diphenyl-2H-tetrazolium bromide) assay. DNA binding studies of compound 6c was performed on Herring-sperm DNA (HS-DNA) andnd MCF-7 cells while a luminescence assay displayed a remarkable increase in the activity of caspase-9 and -3. Moreover, flow cytometric results revealed that compound 6m caused G0/G1 arrest in the treated HeLa? cells. Our results suggested that the compound possesses chemotherapeutic properties against breast cancer and cervical adenocarcinoma cells, thus warranting further research to test the anticancer efficacy of this compound at clinical level.Our results suggested that the compound possesses chemotherapeutic properties against breast cancer and cervical adenocarcinoma cells, thus warranting further research to test the anticancer efficacy of this compound at clinical level. Sanguinarine, a kind of benzophenanthridine alkaloid, is a natural compounds with potential development value for its anticancer activity. Hundreds of studies have been carried out in vivo or vitro, trying to make it feasible for the anticancer clinic medication of sanguinarine. However, sanguinarine was branded a toxicant or even a carcinogen according to some toxicological experiments and cancer investigations. Aimming at safety and effectiveness of sanguinarine, this article reviews the extant information on present studies of sanguinarine, both anticancer are carcinogenesis mechanism details are summarized. The future potential research directions of this valued compound are also discussed to provide reference for future drugs development. PubMed, Web of Science, CNKI and WanFang? databases were used to search current studies and experimental researches about anticancer effect or carcinogenic information of sanguinarine. Our results indicated that sanguinarine exhibited anticancer effect through anti-proliferation, anti-invasion, anti-angiogenesis and apoptosis within cancer lesion. Also, many clinical investigations indicated that sanguinarine and its related products might be associated to pre-carcinoma within oral or skin potentially. Sanguinarine is a natural compounds with good development value for its potent anticancer activity, however, its carcinogenesis effect should also be taken seriously. Studies on structural modification and analogue design should be carried out to improve its safety and efficiency in the future.Sanguinarine is a natural compounds with good development value for its potent anticancer activity, however, its carcinogenesis effect should also be taken seriously. Studies on structural modification and analogue design should be carried out to improve its safety and efficiency in the future. Compound Kushen injection (CKI) is used clinically for relieving cancer pain and treating various solid tumors, particularly lung cancer. However, the underlying mechanisms of CKI in lung cancer remain to be further elucidated. This study aimed to obtain evidence regarding the potential efficacy of the active compounds and therapeutic targets of CKI at a molecular level by using network pharmacology (NP), which is an emerging technique for dealing with complex systems, such as those of herbal medicine. The chemical and predicted target information of CKI was obtained from databases and computational prediction, respectively; lung-cancer drugs and their corresponding targets were retrieved from Drugbank and Drugcentral. The online tool, STRING, was used to gather target-pathway interactions for establishing a target-(pathway)-target network to identify the target group that was most relevant to cancer. Based on this module, a protein-protein interaction network was established for identifying the potential therapeutic targets and the potential active ingredients. CKI might affect lung cancer drug targets or their neighbor nodes to trigger anti-cancer effects. The compounds that were predicted to bind to the potential therapeutic targets were recommended as potential active ingredients of CKI, which included naringenin from Baituling, and kurarinone and isoxanthohumol from Kushen. This NP-based study might provide insights into understanding CKI from the perspective of modern science with reference to approved Western medicine for lung cancer. Moreover, network-based methods could also be further used with distinct advantages in dealing with complex information and systems of medicine.This NP-based study might provide insights into understanding CKI from the perspective of modern science with reference to approved Western medicine for lung cancer. Moreover, network-based methods could also be further used with distinct advantages in dealing with complex information and systems of medicine.The strategy used for the treatment of given brain cancer is critical in determining the post effects and survival. An oncological diagnosis of tumour evaluates a range of parameters such as shape, size, volume, location and neurological complexity that define the symptomatic severity. The evaluation determines the suitable treatment approach chosen from a range of options such as surgery, chemotherapy, hormone therapy, radiation therapy and other targeted therapies. Often, a combination of such therapies is applied to achieve superior results. Radiotherapy serves as a better treatment strategy because of a higher survival rate. It offers the flexibility of synergy with other treatment strategies and fewer side effects on organs at risk. This Review presents a radiobiological perspective in the treatment of brain tumour. https://www.selleckchem.com/products/nor-noha-dihydrochloride.html The cause, symptoms, diagnosis, treatment, post-treatment effects and the framework involved in its elimination are summarized.