tial and therefore in screening of new platinum compounds for low or absent sensitization potential. Additional studies are required to determine whether the DPRA may be successfully applied to other metals. We provide details on method modifications and precautions important to the success of the DPRA in the assessment of metal reactivity. This journal is © The Royal Society of Chemistry 2019.Stiffness following total knee arthroplasty (TKA) can be a devastating complication to the patient by limiting his function. Various causes have been reported in the literature, including heterotopic ossification (HO). HO is one of the rarely reported complication of TKA characterized by deposition of bone cells in non-skeletal tissue. This is a case of 32-year-old female known to have rheumatoid arthritis with history of TKA 4-years-ago complaining of right knee pain and restricted range of motion. She was later found to have HO and was treated with a revision TKA. In conclusion, the incidence and outcome of HO following total knee replacement in patients with RA remains underexplored topic in the literature. Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author(s) 2020.Von Recklinghausen disease (neurofibromatosis type 1-NFT1) is a genetic disorder with autosomal dominant inheritance pattern, caused by mutation of a tumour suppressor gene. Its main features include multiple cutaneous café-au-lait spots and neurofibromas. It is associated with an increased risk of developing neuroendocrine tumours, for instance, in the duodenum. The authors present a case of a 23-year-old male patient admitted to the emergency department due to persistent vomiting. Imaging and biopsy studies revealed an obstructive and large duodenal neuroendocrine tumour; hence the patient underwent a pancreaticoduodenectomy. Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author(s) 2020.Small bowel obstruction is one of the most common causes for acute abdominal pain leading to surgical admissions, occurring most frequently due to postoperative adhesions. https://www.selleckchem.com/products/pha-848125.html Although less common, internal hernia is also a possible etiology, in which a delay on its therapy may lead to a not so dismal morbidity and mortality. Here, we report the case of a 24 year old Caucasian man that was admitted in our emergency department with an inaugural episode of sudden-onset epigastric pain associated with vomiting. After observation and diagnostic workup, the patient underwent urgent laparotomy that revealed an ischemic small bowel due to a double omental hernia, being successfully treated without enteric resection. Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author(s) 2020.Carotid body tumors (CBTs) are rare and usually require complex surgical resection. We present a case of a large 7-cm CBT successfully treated in a community cancer center using a multidisciplinary team approach. A 32-year-old male referred for surgical evaluation of an asymptomatic right neck mass. CT angiography showed a 7-cm tumor encasing the carotid vessels, including the bifurcation (Shamblin III). Preoperative angiography and embolization were performed by interventional radiology. The patient underwent surgical removal of the CBTs and required surgical reconstruction with a common carotid to internal carotid bypass using a polytetrafluoroethylene interposition graft. The hypoglossal nerve, vagus nerve and glossopharyngeal nerve were identified, meticulously dissected and preserved. The patient did well after surgery and recovered with no complications. This report examines the diagnosis, preoperative workup and surgical management of CBTs using a multidisciplinary team approach. Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author(s) 2020.We are reporting a case of internal herniation of the bowel through the foramen of Winslow. This is a very rare condition that prompts an urgent operative intervention due to its potential fatal complications, as it is usually accompanied by bowel strangulation and ischemia. Due to the vague clinical picture, the diagnosis only reached using imaging techniques such as computed tomography or as a surgical surprise during the operation. Key aspects of surgical interventions are hernia reduction, bowel resection in case of non-viable ischemic bowel and the highly debatable recurrence prevention maneouvres. Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author(s) 2020.Although osteochondritis dissecans (OD) is well-described in the bibliography, cases of OD in the 1st metatarsophalangeal joint (MTP) are rare clinical situations. We present a 25-year-old male who presented to our department for big toe pain on the left side. Clinical and radiological examination showed the typical findings of OD lesion on the 1st metatarsal head (MH), establishing the diagnosis of OD. Intraoperatively the articular cartilage of the partially detached part of the MH was intact and under it, an empty cavity with a big defect was obvious. Autogenous cancellous bone transplantation from the metatarsal metaphysis, reattachment of the cartilage surface as a chondral flap and edge sealing with fibrin glue was our treatment of choice. OD of the 1st MH should be included in the differential diagnosis of big toe pain, as early diagnosis and treatment are crucial to prevent future osteoarthritis of the 1st MTP. Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author(s) 2020.Acute appendicitis is the most common surgical pathology worldwide, frequently, the patient history and clinical examination are so similar to other appendicular pathologies that preoperative diagnosis is almost impossible for the medical team. Neuroma of the appendix is a rare tumor of neural origin that usually resembles the symptoms of acute appendicitis. Pathology along with close follow-ups are key, as the diagnosis is based on the presence of nerve neuronal cells in the appendicular lumen. Surgical treatment is recommended due to the possibility of malignancy. We present a case of a 32-year-old male patient who presented with symptoms of acute abdomen, surgery was performed and appendectomy was completed. Neuroma of the appendix was the final diagnosis. Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author(s) 2020. |